No interactions were found between estradiol and vitamin B12. However, this doesn't necessarily mean that there aren't any interactions. Always consult your healthcare provider to ensure that the information shown on this page applies to your personal circumstances. Overall, a higher intake of vitamin B2 was associated with differences in estradiol levels, and both vitamin B2 and B12 intakes were correlated with a small decrease in homocysteine concentrations in healthy premenopausal women, although this needs to be interpreted with care due to the lack of blood measurements. Intake of B vitamins was not largely associated with the risk of sporadic anovulation.
In conclusion, these findings suggest that, with the typical dietary intakes of the American population, B vitamins other than folate, specifically vitamins B2, B6, and B12, which play a key role in single-carbon metabolism, do not appear to greatly influence the ovulatory functioning of healthy premenopausal women. Vitamin B12 is not known to have adverse interactions with hormone therapy and can be taken to improve overall health, especially if there is a deficiency or if there is an increased risk due to dietary restrictions. A literature review suggests that women who use oral medications may experience lower levels of vitamin B1, B2, B3, B12, C and zinc. The use of oral contraceptives has been associated with increased absorption of calcium and copper, and with increased levels of copper and vitamin A in the blood, organic organic compounds may interfere with the absorption of manganese.
The clinical importance of these actions remains unclear. The use of oral medications has been associated with increased absorption of calcium and copper and increased blood levels of copper and vitamin A. OCs may interfere with the absorption of manganese. While hormone replacement therapy offers benefits for managing menopausal symptoms, it's critical to consider associated risks and interactions with other substances, such as vitamins and supplements.
For example, adequate levels of calcium and vitamin D are important for bone health, especially in the context of hormone replacement therapy. Combining vitamin D with hormone replacement therapy is generally considered safe and may be beneficial, especially for maintaining bone health. Many factors can influence homocysteine, but vitamins B6 and B12 act as cofactors for enzymes that have the ability to reduce intracellular homocysteine, while vitamin B2 is a cofactor for MTHFR, an enzyme that produces 5-methyltetrahydrofolate, which is needed to convert homocysteine to methionine. At the screening visit, women were excluded based on specific criteria that included current or recent use of hormonal or oral contraceptives; the use of vitamin or mineral supplements; gynecological problems, including a history of abnormal Pap smears, polycystic ovary syndrome (PCOS), uterine fibroids, or endometriosis; pregnancy or breastfeeding within the past 6 months; and the diagnosis of chronic conditions, such as metabolic or gastrointestinal conditions associated with malabsorption. On the other hand, some studies suggest that vitamins such as vitamin D may have an advantageous effect when taken together with hormone replacement therapy, especially on bone health.
While some are concerned that vitamin D supplements affect hormone levels, research shows that they actually help regulate healthy estrogen production. When undergoing hormone replacement therapy (HRT), patients should be careful with certain vitamins and supplements because of interaction risks that could affect the efficacy or safety of the treatment. Because of the difficulty of measuring hormones and their variability throughout the menstrual cycle in women of reproductive age, it is not surprising that few studies investigate reproductive hormone concentrations and vitamin B intake. We recommend focusing on getting the right amount of vitamin D through sunlight, diet, and doctor-approved supplements to support ideal hormonal balance along with other essential nutrients. Therefore, the objective of this study was to investigate the associations between the intake of vitamins B2, B6 and B12 in the diet and serum concentrations of reproductive hormones and plasma homocysteine and sporadic anovulation in healthy women who regularly menstruated and who did not take dietary supplements.
We found that B vitamins, in particular B6, B9 and B12, play a vital role in estrogen metabolism and hormonal balance. Research shows that when vitamin D levels are low, estrogen synthesis is affected and affects the entire hormonal cascade. However, the scientific community continues to evaluate the risks versus benefits of combining HRT with several vitamins. We have discovered that vitamin D directly influences estrogen production through the regulation of the enzyme aromatase, which is vital for estrogen synthesis.
