Because estrogen creams are absorbed through the skin and go directly into the bloodstream, they are safer than oral estrogen for people who have them. Because estrogen creams are absorbed through the skin and pass directly into the bloodstream, they are safer than oral estrogens for people who have liver and cholesterol problems.
Hormones that are marketed as bioidentical and natural are no safer than the hormones used in traditional hormone therapy.
And there's no proof that they work best for relieving menopausal symptoms, such as hot flashes and vaginal dryness. In addition, some drugs with bioidentical hormones are mixed in a personalized way and their quality can vary greatly.Estradiol is stronger and more effective than estriol. Estriol is a weaker form of estrogen and may have a better safety profile compared to estradiol. However, more clinical trials may be needed on efficacy and safety of estriol. While conventional hormone replacement therapy provides certain benefits, it's not without significant risks.
Estriol has been found to provide some of the protection without the risks associated with stronger estrogens. Depending on the situation, estriol may exert agonistic or antagonistic effects on estrogen. Estriol appears to be effective in controlling menopausal symptoms, including hot flashes, insomnia, vaginal dryness, and frequent tract infections urinal. Research results on its effects on maintaining bone density have been contradictory, and the most promising results come from Japanese studies.
The effect of estriol on cardiac risk factors has also been somewhat ambiguous; however, unlike conventional estrogen prescriptions, it does not appear to contribute to hypertension. While estriol appears to be much safer than estrone or estradiol, continued use at high doses can have a stimulating effect on both breast and endometrial tissue. Vaginal estrogen is safe and effective for most women. Compared to hormone replacement therapy, vaginal estrogen delivers a smaller amount of estrogen directly to the source, so it has no systemic (or whole body) effects that could increase risks for women with a history of certain types of cancer.
In fact, a recent study found that using vaginal estrogen to treat vaginal dryness, urinary problems, and decreased libido is safe for gynecologic cancer survivors. According to the American Academy of Obstetricians and Gynecologists, women with a history of estrogen-dependent breast cancer who don't respond to non-hormonal treatments may consider taking certain topical estrogen formulations. When it comes to oral estrogen, medical studies have shown that oral e2 estradiol is the safest and most effective form, as it avoids the inherent side effects related to encephalocellosis oral. The Women's Estrogen for Stroke Trial (WEST) found that oral estradiol was not associated with increased blood clots, but an increase in blood vessel inflammation and clotting was due to ten biologically active estrogens found in CEE (Premarin).
These active estrogens are not found in estradiol. Estriol is one of the three estrogen hormones. Estriol levels increase during pregnancy, helping to keep the fetus and uterus healthy. Levels are at their highest just before delivery. With regard to VTE, all the studies identified agree that the transdermal route of administration is safer than oral hormone therapy.
The risk of VTE can be considered the clearest and strongest clinical difference between the two routes of administration, confirming that transdermal HRT is safer than oral HRT. While some experts believe that estrogen patches may be safer than oral estrogen in other ways, it's too early to know.
