Overall, a higher intake of vitamin B2 was associated with differences in estradiol and both B2 and B12 intakes were correlated with a small decrease in homocysteine concentrations among healthy premenopausal women, although careful interpretation is necessary given the lack of blood measurements. Intake of B vitamins was not largely associated with the risk of sporadic anovulation. In conclusion, these findings suggest that, with the typical dietary intake of the American population, B vitamins other than folate, specifically vitamins B2, B6 and B12, which play a key role in single-carbon metabolism, do not appear to greatly influence the ovulatory functioning of healthy premenopausal women. Then, we decided to explore related articles to find a justification.
After searching the articles, we found an article in the Women's Encyclopedia of Natural Medicine that dealt with the effect of B complex deficiency on estrogen metabolism and menstruation, and another study on the effect of vitamin B complex supplementation on estrogen levels that was published in the International Journal for Vitamin and Nutrition Research. Both suggested that vitamin B12 and the B complex cause an increase in the level of estrogen, leading to endometrial proliferation. Prolonged bleeding reduces the thickness of the endometrium in hypermenorphic women and causes irregular bleeding, so these two vitamins perform treatment functions. Vitamin B12 deficiency is also often overlooked in cases of infertility and irregular hormonal patterns.
Vitamin B12 is used to break down estrogen so that it can be excreted from the body. As a result, women with vitamin B12 deficiency may experience infertility or irregular cycles because high estrogen levels can result in a lack of ovulation, failed embryo implantation, and difficulty maintaining a pregnancy. Low vitamin B12 levels can also cause hypercoagulability, which is one of the causes of early recurrent miscarriages. Always consult your healthcare provider to ensure that the information shown on this page applies to your personal circumstances.
Vitamin B12 is an essential micronutrient that is needed for more bodily processes than you've probably noticed. However, the universal importance of vitamins B2, B6, and B12 as enzyme cofactors makes connections to the metabolism of sex steroid hormones biologically plausible. If taking supplements is the next step for you, you should consider which form of vitamin B12 is best for your symptomatic condition. I recommend that you take an annual vitamin B12 test every 6 to 12 months, with regular monitoring of your levels if you are receiving vitamin B12 injections to improve your mood, memory, energy, immune system or balance your hormones.
Vitamins B2, B6 and B12 are key players in carbon metabolism as enzymatic cofactors, and deficiency of these nutrients may influence reproductive outcomes, possibly by affecting reproductive hormones. Therefore, the objective of this study was to investigate the associations between the intake of vitamins B2, B6 and B12 in the diet and serum concentrations of reproductive hormones and homocysteine in plasma and sporadic anovulation in healthy women who regularly menstruated and who did not take dietary supplements. Many factors can influence homocysteine, but vitamins B6 and B12 serve as cofactors for enzymes that have the ability to lower intracellular homocysteine, while vitamin B2 is a cofactor for MTHFR, an enzyme that produces 5-methyltetrahydrofolate, which is needed to convert homocysteine to methionine.
