Those who cannot take continuous combined HRT · have ever had an allergic reaction to estrogen or progestin, or to any other medication · have ever had a breast.
Hormone replacement
therapy is not recommended for women who have or have had breast cancer with a hormone receptor positive subtype, such as estrogen receptor (ER) positive breast cancer. Hormonal hormone therapy may slightly increase the risk of breast cancer. If you have had breast cancer, you will usually be advised not to take HRT.Combined hormone therapy is associated with a small increase in the risk of heart attack in older women. This risk may be related to age, existing medical conditions, and the time a woman begins receiving hormone therapy. Some research suggests that combination hormone therapy may protect against heart attacks in women who start combination therapy within 10 years of menopause and who are younger than 60. This benefit may be even greater for women who take estrogen alone. Deep vein thrombosis (DVT) Combined hormone therapy and estrogen-only therapy are associated with a small risk of stroke and blood clots from deep vein thrombosis.
This risk increases with age and other factors, such as heart disease, kidney disease, and obesity. Patches, sprays and rings may pose a lower risk than pills taken by mouth. Hormone replacement therapy replaces hormones that the body doesn't produce in sufficient quantity. Once hormone levels rise, most people find relief from their symptoms.
Hormonal hormone therapy can also help with bone loss (osteoporosis and osteopenia), a common condition in women who don't have enough estrogen. Many experts say that women with a history of breast cancer should not undergo any type of systemic hormone therapy, especially if they have breast tissue (for example, if they underwent a lumpectomy instead of a double mastectomy).).
